Diseases fall under various categories depending on the causative agents or factors. The most common categories are bacterial, fungal, viral, parasitic, degenerative, inherited, and deficiency among others. .One of the diseases caused by the bacterium is gonorrhea attributed to a bacterium called Neisseria gonorrhea. N. gonorrhea is a bacterium that is generally spherical in shape. It occurs in pairs with flattened adjacent sides. Human beings are the only natural host for the bacterium. The N. gonorrhea is efficient in utilizing the transferrin-bound iron for growth. Some also use the lactoferrin-bound iron. The bacterium becomes effective by binding only the human lactoferrin and the transferrin. It is due to the characteristic that the microbe attains recognition as exclusively effective on the human body.Infection of Neisseria gonorrhea is through sexual contact or contact with the fluids of an infected person. The bacterium usually targets the mucus membranes found in the urethra of males’ sexual organ, and the urethra together with the endocervix in females. The organism attaches itself to the cells of nonciliated epithelial using fimbriae or pili. Upon attachment using the pili structures, the organism begins the production of substances called lipopolysaccharide endotoxin (Genco & Wetzler, 2010). On attaching to the nonciliated epithelia of the fallopian tube in women, microvilli surround and move them to the surface having the mucosal cells. The microbe then uses the process of parasite-directed endocytosis to enter into the epithelial group of cells. In that process, the membranes of the mucosal cells retract back to pinch off the membrane-bound vacuoles that carry the bacterium. The next event is usually the transportation of the vacuoles to the bottom of the cells where the release of the bacteria through exocytosis into the subepithelial layer takes place.
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