Metabolic Map-Principles of Biochemistry

Principles of Biochemistry Please construct a “virtual” poster with all the pathways we have discussed from glycolysis to the beta-oxidation of fatty acids depicted inside a cell.  You do not need to include every single reaction but you should include those which are regulated, those that produce or consume energy (ATP, NADH, NADPH), and those at branch points between pathways. For your own benefit, you may want to include a separate list of regulated enzymes and what regulates them.  Please include in your diagram intracellular membranes and locate reactions in the appropriate subcellular location.  Try to include each metabolite only once per subcellular location. Transporters are well worth including. Generating these may be done in PowerPoint using boxes around the metabolites, arrows to indicate reactions, and key enzymes within circles.  Please appreciate that if it appears that all or part of the map is copied and pasted from a resource, no credit will be given.  The making of the map is intended to provide a “synthesizing” experience where connections among pathways and the influence of cellular compartments are better appreciated.  Ideally, this would be done on paper but that is not an option this term. – Please recreate, from scratch, your metabolic map to be similar to the example I posted.  This large diagram should have metabolism in the context of a model cell including the plasma membrane, ER membrane, and a very large mitochondrion with its two membranes.  All pathways from glycolysis through beta-oxidation should be included.  Each metabolite should be written only once in each cellular compartment.  Transporters embedded in the various membranes should be shown.   Please do not skip steps such as glucose > glycogen.  Instead, the steps of glucose > glucose -6-P > glucose 1-P + UTP > PPi + UDP – glucose > glycogen should be included.

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